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Medication That Is Used In The Treatment Of Moderate To Severe Pain

Tramadol, also sold under brand names Ultram and Ultram ER, is a narcotic pain reliever used in the treatment of moderate to severe pain The extended-release (ER) version is used to treat chronic pain that requires 24-hour maintenance. In addition, there may be other uses for this medication.

Before taking Tramadol, it is important to discuss with your doctor whether you have ever been addicted to drugs or alcohol. This is important because Tramadol should not be taken when one is intoxicated or by those who have recently used drugs such as alcohol, other narcotic pain medications, medication for the treatment of depression or anxiety, tranquilizers such as Valium, medicine for the treatment of mental illness such as schizophrenia, or street drugs.

Further, although the risk of seizure is present for all users of Tramadol, this risk may be significantly higher in those who have certain medical conditions. For that reason, it is important that you tell your doctor if you suffer from any of the following conditions: a history of drug abuse, epilepsy or seizure disorder, previous head injury, or a metabolic disorder.
Other disorders that may make Tramadol contraindicated include kidney disease, liver disease, any disorder of the stomach, or a history of depression or mental illness.

If you are pregnant and considering taking Tramadol, it is important to know that the drug is in pregnancy category C. This means that the medication may be harmful to an unborn baby, and it may also cause serious - or even fatal - side effects in a newborn if it is administered to the mother during pregnancy or labor. Note, too, that Tramadol can enter a mother's breast milk and can therefore be harmful to a nursing baby.

Age is a factor in a patient's suitability for Tramadol, too. It should not be given to anyone under 16 years of age, and for those over 65 a lower-than-usual dose may be recommended. Finally, take Tramadol exactly as it has been prescribed. Take it with a full glass of water and do not crush the tablet. You may take it with or without food, but whichever way you choose, be sure to take it the same way every time.

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The Unique Pain Medication

Tramadol has been used as an analgesic since the late 1970s, and became one of the most popular analgesics of its class in Germany. International interest for the drug has been renewed when it was discovered that tramadol not only acts like opioids, but also inhibits serotonin and noradrenaline reuptake.

Mechanism of action

Tramadol is a unique medication. Its mode of action and safety profile distinguishes it from other opioids. It is classified as an atypical centrally acting analgesic, and has opioid and non-opioid properties. Tramadol is a synthetic analogue of codeine that has weak opioid agonist properties. It also inhibits the neuronal reuptake of norepinephrine and serotonin as do the antidepressant drugs

Tramadol has strong structural similarities to the antidepressant venlafaxine. Because of its similarities to venlafaxine, tramadol may possibly exert a degree of antidepressant effect in certain patients, particularly those with chronic pain.

Side effects

Tramadol is generally well tolerated, the most common side effects being nausea and vomiting. In contrast to agents such as morphine and pethidine, respiratory depression rarely occurs during tramadol treatment at equipotent doses. But large doses of tramadol may increase the respiratory effects of other drugs. It is also associated with a low incidence of cardiac depression and significantly less dizziness and drowsiness than morphine.

Finally, dependence and abuse potential is relatively low because it has only a weak opioid effect. The low abuse potential of tramadol has been demonstrated by postmarketing surveillance data.

Tramadol appears to carry the same risk of urinary disorders (difficulty in micturition, urinary retention) as other opiates.

The medication should be avoided in persons with epilepsy and used cautiously in those taking medications which lower the threshold for seizures.

Tramadol uses

It is effective in different types of moderate-to-severe pain, including neuropathic pain. This medication has a dose-dependent efficacy that lies between that of codeine and morphine, with a parenteral potency comparable to that of pethidine.

Comparative studies have demonstrated that tramadol is more effective than NSAIDs for controlling post operative pain. Moreover, as the mode of action of tramadol does not overlap with that of NSAIDs, it is a useful agent to be combined with these drugs. Use of a combination of tramadol and NSAIDs allows the tramadol dose to be reduced and results in a lower incidence of side effects.

Tramadol may be particularly useful for elderly population suffering from osteoarthritis because, unlike NSAIDs, it does not aggravate high blood pressure and cardiovascular complications, nor does it have the potential to cause peptic ulcer disease.

Tramadol has been used with good results for the management of labour pain without respiratory depression of the neonate. It is effective for the treatment of pain from myocardial ischaemia, renal colic and acute trauma.

Recommendations

The recommended daily dose of tramadol [http://www.emedexpert.com/products/tramadol.shtml] is between 50 and 100mg every 4 to 6 hours, with a maximum dose of 400 mg/day; the duration of the analgesic effect after a single oral dose of tramadol 100 mg is about 6 hours. Yury Bayarski is the contributing author of eMedExpert.com. More information about tramadol is available on author's website.

Top Important 10 Things You Need to Know About Pain Drugs

Top important 10 things you need to know about tramadol

Tramadol represents one of the best analgesic drug which treats moderate and chronic pain. How this drug works is still an unknown thing for the medical world, but the action of this medicine are very similar to morphine, while the secondary effects are a lot less harmful. Here we are going to present you 10 things about tramadol, which you should know before taking it.

1. Tramadol is used in order to treat moderate to severe pain. This drug is a synthetic analgesic that works on your body by changing the way your brain receives the pain from the nerves.

2. The tramadol maximum daily dose is 300mg. However the recommended dose during the moment you start taking this drug is going to be only 100mg and you can increase it by 100mg every 5 days until you reach the maximum.

3. Overdose of tramadol can be fatal. You must never go above the safeguard dose of 300mg of tramadol, because tramadol overdose has some serious side effects and in some cases it can become fatal.

4. Tramadol can be addictive. This way if you have a history of addiction it's best that you don't take this drug, since you're most likely to become a tramadol addict.

5. Combining tramadol with other drugs can be dangerous. Make sure that before taking any other pills you contact your doctor in order to be sure that the interaction is not going to have a harmful effect on your body.

6. There are some tramadol side effects that can be spotted at a small percentage of the patients. This includes: nausea, constipation, dizziness, headache, drowsiness and vomiting. In case of more severe side effects get in touch with the doctor that prescribed you the pill.

7. Pregnant and nursing women should avoid taking tramadol, since it might have a negative impact on the baby.

8. Tramadol is not considered to be a controlled drug by FDA.

9. You can buy tramadol online for a price 2-3 times lower compared to a retail pharmacy.

10. Tramadol is one of the most popular pain relief pills in the world.

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